Sequence variation: Looking for effects of genetic linkage

نویسندگان

  • Deborah Charlesworth
  • Brian Charlesworth
چکیده

Selection at linked loci probably reduces the variability of genes in regions of infrequent recombination. Detailed sequence information is needed to test possible causes of this effect; such information is now becoming available, but its interpretation can be difficult.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Single Nucleotide Polymorphisms and Association Studies: A Few Critical Points

Uncovering DNA sequence variations that correlate with phenotypic changes, e.g., diseases, is the aim of sequence variation studies. Common types sequence variations are Single nucleotide polymorphism (SNP, pronounced snip).SNPs are the third-generation molecular marker. SNP represents a DNA sequence variant of a single base pair with the minor allele occurring in more than 1% of a given popula...

متن کامل

Looking for Genetic Diversity in Iranian Apple Cultivars (Malus × domestica Borkh.)

The cultivated apple (Malus domestica) is one of the most important fruit crops cultivated in different regions of the world including Iran. For production and breeding of high quality apple, the knowledge of genetic diversity of the cultivated apples  is  necessary. Therefore we studied genetic diversity of 25 genotypes by using ISSR molecular markers. In present study, ten ISSR primers produc...

متن کامل

Genetic Variation Among Salvia Species Based on Sequence-Related Amplified Polymorphism (SRAP) Marker

In this study, SRAP molecular maker approach was performed to investigate genetic diversity in the Salvia genus. A total of 205 DNA bands were produced from PCR amplification of 11 Salvia species and populations using 25 selective primer combinations, of which 204 polymorphic genetic loci accounted. The total number of amplified fragments ranged from 3 to 15. The genetic similarities of 11 coll...

متن کامل

Molecular diversity within and between Ajowan (Carum copticum L.) populations based on inter simple sequence repeat (ISSR) markers

Study of genetic relationships is a prerequisite for plant breeding activities as well as for conservation of genetic resources. In the present study, genetic diversity among and within 15 Iranian native Ajowan(Carum copticum L.) populations were determined using inter simple sequence repeat (ISSR) markers. Twelve selected primers produced 153 discernible bands, with 93 (60.78%) being ...

متن کامل

PCR-SSCP Analysis of Genetic Variation in DNMT Gene Family in Holstein Cattle

Members the DNA Methyltransferases (DNMT) gene family have been shown to play fundamental roles in regulating embryonic growth and development from embryonic fertilization to postnatal life; through regulating the establishment and/or maintenance of specific epigenetic marks. The present study was conducted to identify potential reported mutations within the exon 33 of DNMT-1, intron 4 of DNMT-...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Current Biology

دوره 8  شماره 

صفحات  -

تاریخ انتشار 1998